4784 The Efficacy of Autologous Platelet Gel In Cervicofacial Rhytidectomy: A Prospective,Randomized, Controlled Trial

Sunday, May 8, 2011: 11:00 AM
Carlos Calixto, Plastic Surgery - Post Graduation Program, UNIFESP- Federal University of Sao Paulo, Sao Paulo, Brazil, Luis Eduardo Felipe Abla, MD, PhD, Plastic Surgery, Federal University of Sao Paulo, São Paulo, Brazil and Lydia Masako Ferreira, Professora, Titular, da, Disciplina, Cirurgia, Plástica, UNIFESP, Chefe, do, Departamento, Cirurgia, UNIFESP, Pesquisadora, CNPq, 1B, Head and Full Professor Plastic surgery division Federal University of São Paulo, Searcher CNPq 1 B, Head Surgery Department UNI, São Paulo, Brazil

Objective: The purpose of this study was to evaluate a new technique

of harvesting and preparing autologous platelet gel

and autologous fibrin glue (body glue) and to evaluate

their effectiveness in stopping capillary bleeding in the

surgical flaps of patients undergoing face-lift. 


A sample of 40 patients ranging from 35  to 72

years of age undergoing face lift  involving the

creation of a surgical flap were included in the study. The

types of surgical procedures included face lifts, and neck lifts.

Platelet poor and platelet-rich plasma were prepared during the

procedure from autologous blood using a compact, tabletop,

The platelet-poor and platelet-rich plasma

were combined with a thrombin-calcium chloride solution

to produce autologous fibrin glue and autologous platelet

gel, respectively. 


Capillary bed bleeding was present in all

cases and effectively sealed within 3 minutes following the

application of platelet gel and fibrin glue. Patients  treated with APG demonstrated less edema and/or ecchymosis.


 Platelet Rich Plasma (PRP) is an autologous preparation currently used in plastic surgery. Blood collection and preparation of platelet concentrates may lead to platelet activation and the premature loss of their granular load. In this study, we have analyzed the quality of the PRP obtained from

a small volume of whole blood through a double centrifugation technique, so called "tube method".

 Autologous platelet gel and fibrin glue prepared by the automated concentrate

system are similar as with autotransfusor-prepared platelet

gel and could be compared with Tisseel (Baxter Healthcare Corp.), a commercially

prepared fibrin sealant preparation.

The technique for making the solution and for evaluating its effectiveness in achieving and maintaining hemostasis during surgical procedures is described.


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